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NAD+ wholesale: sizes, stability and what clinics get wrong

Jonathan Cole · · NAD+ Operations

NAD+ is one of the highest-margin, highest-volume products a clinic or pharmacy can stock, and one of the most mishandled. The molecule is stable when lyophilized and cold, and degrades quickly in solution at room temperature. Most quality complaints trace back to storage, not the source.

Formats

Wholesale NAD+ is supplied as lyophilized powder in 500 mg and 1000 mg vials, or as bulk API for pharmacies compounding their own vials. Pre-made solution has a short shelf life and is usually the pharmacy's job, not the supplier's.

Storage and handling

Lyophilized at −20 °C long-term, shipped 2 to 8 °C with a temperature indicator. Once reconstituted, keep refrigerated and use within the pharmacy's beyond-use date. Clinics that leave reconstituted NAD+ on a counter get a yellowing solution and a patient complaint.

Documentation

Lot-specific CoA with HPLC purity and identity. Endotoxin and sterility on injectable-grade vials. NAD+ is a common target for adulteration with cheaper nicotinamide, so identity testing matters more than usual.

Demand planning

Clinic demand is protocol-driven and lumpy: a new NAD+ program can triple monthly volume in one month. Set an allocated inventory with your supplier once you have two months of history, and order on a schedule rather than when the fridge is empty.

Pricing

NAD+ pricing scales sharply with volume. Ask for tiers at 100, 500 and 1000 vials per month before committing to a supplier; the gap between tiers is often larger than the gap between suppliers. Verified accounts see current tiers in the catalog.